How can sleep 2 hours be able to spirit a whole day? The fruit fly gives the answer
With the in-depth study of the mechanism of deep sleep, it may not need more than 8 hours of adequate sleep in the future, by regulating the depth of sleep, you can replenish your energy in a faster time.
Sleep 2 hours, the spirit of the whole day. Such a dream is being gradually illuminated by the efforts of scientists into reality.
A piece of information from Zhejiang University provides a very important experimental basis for explaining the connection mechanism between circadian circuits and sleep circuits.
Guo Fang, a researcher at the university’s medical school, has identified the circadian rhythmic neuron APDN1 in the brain of the Drosophila melanogaster as a neural circuit connected to the ellipsoid EB-R2, a sleep homeostasis center, a reporter from the Science and Technology Daily has learned.
Through research, future drugs can cure insomnia, so that patients with light sleep have better quality of sleep.
The researchers also speculate that, as the mechanism of deep sleep is further studied, it may not take more than eight hours to get enough sleep in the future. By regulating deep sleep, the researchers may be able to replenish their energy in a faster time. It’s possible to sleep for two hours and be mentally active all day.
If the results of this study can be used, it will have a great impact on human progress.
Tracking the progression of circadian rhythm neurons
Related results have been published in the well-known journal Neuron. It is worth mentioning that the winners of the Nobel Prize in Physiology and Medicine in 2017, Professor Michael Rossbush of Brandeis University and Prof. Guo Fang are co-authors of the paper.
Drosophila’s circadian rhythm neuron APDN1 is a valve that controls sleep, and Guo Fang and his mentor, Roth Barthes, confirmed this in previous studies. In 2016, scientists at Johns Hopkins University have identified neurons in Drosophila that regulate sleep homeostasis as ellipsoid EB-R2.
Exploring the relationship between APDN1 and ellipsoid EB-R2 is the main line of Guo Fang’s research.
The Guo Fang team found that the APDN1 neurons of Drosophila had two clusters of projections that were directed to the anterior and posterior sides of the Drosophila brain. The role of the backward cluster has been confirmed, and which brain region is projected to the forward cluster, what is the biological function, it is not known.
The Guo Fang team used the newly invented neural circuit technology, trans-synaptic display technology, to track the direction of the projection neurons. Then, through the expansion microscope, the brain of the fruit fly was amplified and transparent, and the axon was projected forward to an AOTU. Brain area.
Calcium imaging techniques indicate that they dominate a specific group of TuBu neurons and are coupled to the ellipsoid EB-R2, the center of sleep stability in the higher brain regions.
Find a “firewall” that blocks information from the outside world.
Finally, Guo Fang’s team identified the neural circuits of the dorsal rhythmic neuron APDN1 projecting to the sleep homeostasis center and ellipsoid EB-R2 of Drosophila melanogaster. The neuronal APDN1 acts as a “switch” that regulates the APDN1 activated by the EB-R2, to induce specific oscillatory patterns in the EB-R2 similar to those in human sleep.
Through behavioral experiments such as optogenetics, Guo Fang also found that a specific oscillation pattern in the EB-R2 of Drosophila is a “firewall” that can “block” the input of information from the outside world, making the fly insensitive to external stimuli. “when the ‘firewall’ is broken by artificial means, the fruit fly is unable to enter a deep sleep. “Guo Fang said.
The study of the “firewall” of sleep is still a starting point. Guo Fang told the reporter that the scientific problem that remains to be solved at present is how the “firewall” will prevent the introduction of information from the outside world, what the transmitter of this neural circuit will be, and the specific internal mechanism, and so on. They will conduct further in-depth research.