Anti-aging stem cells also grow old
Stem cell is one of the most cutting-edge and cutting-edge science in life science.
Since the first human bone marrow stem cell transplantation was completed in 1969, stem cell research has developed rapidly. In recent years, related fields have been awarded the Nobel Prize in Physiology or Medicine for many times. The in-depth study of stem cells may reveal the causes of aging from a deep level, and ultimately realize the dream of delaying the aging of human beings.
Ancient Greece has the legend of “the fountain of immortality”, and ancient China has the story of the “elixir of immortality”. With the progress of medical technology and the improvement of living environment, the average life span of human beings has been greatly increased, but it is still facing the limit.
With aging, the likelihood of a range of diseases increases dramatically, affecting not only life expectancy but also the quality of life in old age. Aging healthily and gracefully has become an important challenge for biomedical research in the new era.
Aging is caused by the decline in the sexual functions of all the organs that make up the human body, the “parts and components” of the body.
Most human organs are capable of self-renewal, and newly formed cells can replace damaged or abnormal cells.
It is known that in almost all organs there is a special kind of cells, which can continuously produce new multifunctional cells to supplement and repair damaged organs, this special cell is stem cells.
Stem cells can not only work in vivo, a variety of stem cells can also be cultured in vitro and transplanted into the body. Stem cell transplantation is one of the important methods to treat leukemia and other hematological diseases.
However, stem cells are not immortal, they also age, and may be an important cause of aging in the human body. In other words, if we can avoid, correct or delay the aging process of stem cells, we can theoretically improve the aging process.
The cause of stem cell senescence is the most advanced and active branch in the field of senescence research.
One theory is that DNA accumulates false information over time, causing genetic information to fail to replicate steadily and cells to age.
The autophagy hypothesis holds that cells have the ability to clear out abnormal or necrotic structures, and once this ability is impaired, the ranks of cells will be filled with “bad cells.”
The hypothesis of mitochondrial and metabolic regulation holds that the maintenance of stem cell function depends on the normal energy metabolism, especially the stability of intracellular “energy factory” mitochondrial function, the abnormality of cell metabolism and the damage of mitochondrial function will lead to the senescence of stem cells.
In the end, what kind of power is eating the vitality of stem cells, it is obvious that the academic community needs to do in-depth and meticulous research.
Because of the complexity of stem cell senescence, only a few methods have been found to inhibit stem cell senescence.
The latest research found that artificial drug intervention to improve mitochondrial activity can directly delay the aging of a variety of stem cells, treatment of skeletal muscle atrophy disease in mice, and can increase the life of about 10% of mice.
Clinical trials are under way in humans, and a “secret recipe” for truly effective protection against aging and related diseases is expected to emerge.
In addition, improve the ability of cell autophagy, accelerate cell “self-renewal”, can also achieve the purpose of preventing premature senescence of stem cells.