How does caffeine perk you up? What is the principle?

In this article, we give a lively look at how caffeine works and why it sometimes doesn’t. From brain sleepiness to caffeine to stop it, you’ll love this fun article!

How do we get sleepy?

In our body’s most advanced control center, the brain, there are certain adenosine receptors (in the central nervous system) that are important to the body.

Let’s first look at what adenosine receptors are!

As the name suggests, it’s the thing that binds adenosine, and when the adenosine receptor binds adenosine, the neuromodulator, it starts doing all sorts of things to your body.

Such as sleep, learning, memory, depression and so on.

We’ll just talk about sleep today. When you’re feeling tired: I’m sleepy and need some sleep.

At this point, the adenosine receptors in the brain go and bind to adenosine!


Because adenosine is the homeostatic factor that regulates sleep in the body, various reactions occur after binding!

You will be surprised to find that your nerve cell activity is reduced, everyone is not moving, lazy ~

The brain a Chou, how all such condition? ! Oh, come on, let’s get some sleep and work tomorrow.

The cells say ok, and then they go to rest, and then you fall asleep.

This is what we call sleepiness…

How does caffeine work?

Next, let’s take a look at what caffeine does!

As the caffeine slowly enters the body, wandering around it comes across adenosine, which is actively binding to the adenosine receptor!

But when it was surprised to find that its chemical structure was very similar to adenosine, it thought: unfair! I’m so similar to your chemical structure, why can you bind to the receptor, and I can’t?

So coffee starts competing with adenosine for receptors.

Because of the competing receptors, caffeine kicks out adenosine and overtakes all the adenosine receptors, so the cells have no way to sense adenosine.

Originally, the body was very tired and kept uploading signals to the brain to apply for a rest, but as a result, the brain could not receive the signal needed for a rest, so it could only work hard all the time.

So, caffeine can block sleepiness and boost energy levels in the short term. It doesn’t mean it eliminates fatigue. It just tricks the brain into temporarily not receiving the “need to rest” signal.

As a result, when it’s time to go to bed, the body doesn’t feel sleepy due to caffeine consumption and remains active.

Moreover, because caffeine blocks adenosine, neurons in the brain fire more. The pituitary gland is quick to notice the condition, and it doesn’t feel right.

He’s thinking, huh? ! Why are all kinds of neurons firing all of a sudden? ! There must be an emergency in the airframe. The adrenal glands are stimulated to produce adrenaline.

Let’s take a look at the effects of epinephrine, in the jargon:

  • This causes the airways to open (which is why people sometimes have to be given epinephrine during severe asthma attacks)
  • Make your heart beat faster
  • Constricting blood vessels slows the bleeding from the wound and increases blood flow to the muscles. Blood pressure to rise
  • Slows blood flow to the stomach
  • The liver releases sugar into the bloodstream for extra energy
  • Muscle tension

This explains why after drinking a large cup of coffee, your hands get cold, your muscles tense, you get excited and even your heart beats faster!

Why do I feel more sleepy after drinking coffee?

First, no amount of caffeine, however powerful, can eliminate individual differences.

Everyone has a different constitution and reacts differently to coffee.

Caffeine has little effect on some people, and some people are very sensitive to caffeine. (for those who prefer coffee but don’t want to be affected by caffeine, consider decaf.)

Here’s why some people can fall asleep immediately after drinking four strong cups of coffee in the evening!

There are three factors that cause coffee to have different effects on people:

  • age
  • gene
  • habit

Let’s start with age, because as we get older, there are fewer receptors in the brain that can dock with caffeine. A 60-year-old person has less than a third as many receptors in his brain as a 20-year-old, so coffee tends to have less effect on older people.

Then there are the genetic reasons: everyone has different receptors in their brains because of their genes. Some people’s brains are more receptive to caffeine — and coffee is especially effective for these people.

Finally, there is the habit factor: if you drink a lot of coffee over a long period of time, the brain will release fewer receptors, which is an adaptation of the body — the effect of coffee will be smaller and smaller because of the habit. Just like running, if you run regularly for a long time, your body will adapt to it. Therefore, we advocate multi-speed running when working out, and multiple forms of exercise can stimulate your body.


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