Is it lucky not to feel pain?

Is it lucky not to feel pain?

According to Xinhua News Agency, a 71-year-old Scottish woman, Joe Cameron, has never felt any physical pain[1].

When she was 8 years old, she accidentally broke her arm and didn’t cry out for pain. Even the pain of giving birth to a child was as if nothing had happened to her.

The study found that Cameron’s “no pain” was due to a genetic mutation in her body.

A few days ago, a research paper on this rare case was published in the British Journal of Anesthesiology.

The discomfort, pain and suffering brought by pain make human psychology resist, but if the body does not feel pain, is it really a good thing?

Is it lucky not to feel pain?
Is it lucky not to feel pain?

Why doesn’t she feel pain?

Cameron had no “secret” of pain and was not discovered by doctors until her two visits to the doctor after she entered old age.

When Cameron was 65 years old, he went to see a doctor for hip problems. Doctors found that although she suffered from severe degenerative hip disease, she did not feel any pain.

When she was 66 years old, she had a hand operation but with an easy grace did not suffer as other patients did.

After two surgeries, the doctors felt strange about Cameron’s lack of pain and asked her for a consultation. Only then did they find out that one of her genes had mutated.

This gene is FAAH-OUT, which used to be considered as a useless junk gene, but in fact all genes have their rationality.

FAAH-OUT regulates the expression of FAAH gene and reduces the activity of FAAH gene, which happens to be one of the genes causing pain and anxiety[2].

Cameron lost his pain due to a mutation in FAAH-OUT.

The absence of pain also made her free from anxiety, worry and fear, and even depression that ordinary people may experience at a certain time.

Cell and animal studies and human genetic studies have shown that inhibition of FAAH may be a useful strategy for the treatment of anxiety disorders[3].

What’s more, if Cameron is injured, the wound will be repaired very quickly and few scars will be left.

Doctors believe that genetic factors may be found in Cameron’s family, because her father has never taken painkillers.

Unfortunately, her father has passed away, and it is impossible to know whether her FAAH-OUT gene mutation originated from her father, while Cameron’s mother did not have FAAH-OUT gene mutation after gene testing.

At the same time, Cameron’s children did not find mutations in the FAAH-OUT gene.

Therefore, Cameron’s family feels pain.

Painless disease is a hereditary neurological disorder

Cameron seems to be a lucky person in life because he does not feel pain, but no pain is actually an abnormal manifestation and a disease, such as painless.

There are many reasons for pain loss or painless disease.

In patients with congenital anodynia, most of them are caused by gene mutation caused by nerve hypoplasia, which leads to hyperalgesia, usually accompanied by other disease symptoms.

Previous studies have called congenital anodynia hereditary sensory and autonomic dysfunction (HSAN), which is mainly caused by ectodermal dysplasia during embryonic development.

It is divided into five types:

  • The mutant gene of HSAN type 1 is called SPTLC gene.
  • The mutant gene of HSAN type 2 is called HSN gene.
  • The mutant gene of HSAN type 3 is called IKBKAP gene.
  • The mutant gene of HSAN type 4 is called NTRK gene.
  • The mutant gene of HSAN type 5 is called NGFB gene.

Why is it said that no pain may be a kind of luck, but it is accompanied by other misfortunes? To give a few examples.

Type 3 HSAN is also called Reilly-Dai syndrome. Such patients are born with light weight, sensory loss and sympathetic dysfunction, small crying, weak sucking and no tears. They are prone to pneumonia, slow growth and development, and often suffer from paroxysmal vomiting, excessive sweating, diarrhea or constipation, muscle spasm, motor dysfunction, ataxia, pain loss and other symptoms.

Moreover, patients with type 3 HSAN will have a series of diseases caused by autonomic nerve development defects after the age of 3, such as excitability, fast heart rate, elevated blood pressure and fluctuating body temperature.

In primary school, type 3 HSAN patients are usually shorter than other normal children, with unstable walking and poor academic performance.

Upright hypotension, syncope, emotional instability, etc. will occur during puberty, and normal physical exercise will not be allowed.

In addition, most children with no pain will die of pneumonia or other complications.

The pathogenic gene of HSAN type 4 is caused by tyrosine receptor kinase 1(NTRK1) gene mutation, and the tyrosine receptor encoded by HSAN type 4 is necessary for nerve growth factor. This gene mutation will inevitably lead to abnormal growth and development of human beings.

Patients with type 4 HSAN and type 5 HSAN have both painless symptoms and sweating[4].

Therefore, these patients may not only have the happiness of not feeling pain, but also have the pain of not sweating.

Because they can’t sweat and dissipate heat, they will have repeated fever symptoms, and others will be accompanied by mental retardation, fracture, osteomyelitis, etc.

In addition, not feeling pain is also a dangerous thing.

People with this disease usually die in childhood due to injury or disease, especially when burns occur[5][6].

Lack of pain can bring so many problems

Many times in one’s life, one will accompany and dance with pain.

The negative impact of pain is obvious. It will lead to a large amount of energy consumption, loss of appetite, sleeplessness and listlessness of human body, which will further lead to the decline of immune function. Severe pain will also make people enter a state of exhaustion quickly.

Even toothache is enough to upset people and seriously affect appetite and sleep, as well as life, work and study.

Pain caused by childbirth, cancer or other chronic diseases may even cause some people to have extreme behaviors.

Human pain is mainly conveyed by nerve sensation. Human suffering is mainly expressed by spirit (brain consciousness), and the two are related.

In life, the vast majority of people have physical pain, there will be mental pain.

Even so, scientists do not believe that no pain is happier than normal people.

Because, as mentioned above, most people with hyperalgesia have other symptoms that are difficult to treat.

Cameron is lucky to have no pain and no accident, but more pain-free people are unfortunate and painful.

The so-called “pain” in modern medicine is a complex physiological and psychological activity and is one of the most common clinical symptoms.

It includes the pain sensation caused by the nociceptive stimulus acting on the body and the pain response of the body to the nociceptive stimulus (somatic motor response and/or visceral plant response, often accompanied by strong emotional color).

Pain sense can be used as a warning of body injury, causing a series of defensive protective reactions.

On the other hand, pain, as an early warning signal, also has its limitations. For example, when cancer-induced pain occurs, it has reached a relatively serious level.

Pain is a natural stress reaction of the body, which can give early warning to the pain sufferer.

The lack of pain will cover up the symptoms of the disease and lose the best treatment opportunity.

New research has also found that pain is of great significance to organisms.

For example, a pain nerve expressing Nav1.8 ion channel can inhibit inflammatory reaction and bone degeneration caused by fungal infection.

In addition, patients with painless diseases are more serious when they are young.

  • Because there is no pain, children cannot make normal reflex actions to dangerous situations, such as fire, boiled water, etc.
  • Children also have no feeling of biting their tongue, lips and various traumas. In extreme cases, similar self-harm may occur.
  • Children often fall and do not know how to prevent them, resulting in bone fracture deformation, dislocation of joints, and repeated occurrence of ischemic necrosis of hip joint, which will lead to serious infection, osteomyelitis and septicemia.

Alleviating pain is the goal

Of course, if the pain can be reasonably relieved and the pain reduced, it will help relieve people’s anxiety, uneasiness and pain.

New research has found that relieving pain can help metabolism and prolong life.

Professor dilling’s team at the university of california, berkeley tested mice with CGRP (calcitonin gene-related peptide) inhibitor, which can block the pain caused by TRPV1[7].

The results showed that the aged mice could recover their metabolic health after taking the medicine, and blocking TRPV1, a pain receptor, to relieve pain could not only relieve pain, but also improve the life span of mice.

If this mechanism can be embodied in people, it can not only be used to treat diabetes and obesity, but also its analgesic effect may help prolong life.

At present, researchers are developing painkillers for various pain genes, such as TRPA1 gene, SCN9A gene, SCN11A gene, μ opioid receptor gene, etc.

Similarly, the FAAH-OUT gene found in Cameron can also be used as a gene site for analgesic drug research and development.

With drugs for pain caused by different causes and different genes, pain can be alleviated.

Therefore, alleviating pain is the goal that the medical profession is worth achieving.

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